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1994-09-03
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Document 0081
DOCN M9490081
TI Hybrid Ty virus-like particles.
DT 9411
AU Adams SE; Burns NR; Layton GT; Kingsman AJ; British Bio-technology Ltd.,
Oxford, U.K.
SO Int Rev Immunol. 1994;11(2):133-41. Unique Identifier : AIDSLINE
MED/94321837
AB Vaccines need to activate antigen presenting cells, overcome genetic
restriction in T-cell responses and elicit both T and B memory cells. In
order to produce recombinant vaccines which can do this, considerable
effort has been put into developing particulate antigen presentation
systems to generate polyvalent, high molecular weight antigens which
should maximally stimulate the immune system. One such antigen-carrier
system is based on the ability of a protein encoded by the yeast
retrotransposon, Ty, to self-assemble into virus-like particles (VLPs).
Ty-fusion proteins retain this ability to form particles and a range of
hybrid VLPs carrying a variety of heterologous antigens have been
produced and shown to elicit potent immune responses. Hybrid VLPs
carrying human immunodeficiency virus (HIV) antigens stimulate the three
main components of the immune system, namely antibody synthesis, T-cell
proliferative responses and cytotoxic T-lymphocyte (CTL) responses.
DE Animal Antigen Presentation/IMMUNOLOGY B-Lymphocytes/IMMUNOLOGY *DNA
Insertion Elements Fungal Proteins/*IMMUNOLOGY Genetic
Vectors/*IMMUNOLOGY Recombinant Fusion Proteins/*IMMUNOLOGY/PHYSIOLOGY
Saccharomyces cerevisiae/*GENETICS T-Lymphocytes,
Helper-Inducer/IMMUNOLOGY Viral Proteins/*IMMUNOLOGY JOURNAL ARTICLE
REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).